The steroid metabolite 16(β)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1

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• 作者：J. Neunzig^a ; M. Milhim^a ; L. Schiffer^a ; Y. Khatri^a ; J. Zapp^b ; A. Sá ; nchez-Guijo^c ; M.F. Hartmann^c ; S.A. Wudy^c ; R. Bernhardt^a ; ^{ritabern@mx.uni-saarland.de}
• 关键词：16bOHA4 ; 16beta hydroxy-androstenedione ; DOC ; deoxycorticosterone ; A4 ; androstenedione ; E1 ; estrone ; AdR ; adrenodoxin reductase ; E2 ; estradiol ; Adx ; adrenodoxin ; ER ; estrogen receptor ; AR ; androgen receptor ; FAD ; flavin adenine dinucleotide ; CPR ; cytochrome P450 reductase ; FMN ; flavin mononucleotide ; CYP ; cytochrome P450 ; p16bOHE1 ; putative 16beta hydroxy-estrone ; DHEA ; dehydroepiandrosterone ; RSS ; 11-deoxycortisol ; DLPC ; dilauroyl phosphatidylcholin ; T ; testosterone
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：182-191
• 全文大小：2133 K
• 卷排序：167

文摘

Novel activity of CYP21A2 elucidated. Discovery of the steroid intermediate 16beta-hydroxy-androstenedione. Potential diagnostic marker for endocrine diseases found. New substrate for CYP19A1 identified. Potential aromatase inhibitor found.