Effect of cadmium administration in hyperhomocysteinemic mice due to cystathionine beta synthase deficiency
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- 作者：Camille Ramambasona ; 1 ; Gautier Moroyb ; 1 ; Fabrice Daubigneya ; Jean-Louis Paulc ; Nathalie Janela ; janel@univ-paris-diderot.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CBS ; cystathionine beta synthase ; GSH ; glutathione ; Hcy ; homocysteine ; HHcy ; hyperhomocysteinemia ; HO-1 ; heme oxygenase I ; PON1 ; paraoxonase 1 ; NQO1 ; NAD(P)H ; quinone oxidoreductase ; XME ; xenobiotic-metabolizing enzyme
- 刊名：Experimental and Toxicologic Pathology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：68
- 期：6
- 页码：365-370
- 全文大小：752 K
文摘
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Cadmium daministration has no effect on plasma homocysteine level.
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Plasma glutathione level is decreased in hyperhomocysteinemic mice compared to control mice after cadmium administration.
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Cadmium administration has the same effect on PON1 and NQO1 activity in control and hyperhomocysteinemic mice.
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Cadmium could be able to prevent the binding of calcium to two calcium-dependent enzymes.