Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis and promotes cell proliferation and resistance to oxidative stress

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• 作者：Ricardo Sá ; nchez-Rodrí ; guez^a ; Julia Esperanza Torres-Mena^a ; ^b ; Valeria Quintanar-Jurado^a ; Victoria Chagoya-Hazas^c ; Emilio Rojas del Castillo^d ; Luis del Pozo Yauner^a ; Saul Villa-Treviñ ; o^b ; Julio Isael Pé ; rez-Carreó ; n^a ; ^{jiperez@inmegen.gob.mx}
• 关键词：PTGR1 ; Prostaglandin reductase 1 ; HCC ; Hepatocellular carcinoma ; 4-HNE ; 4-hydroxynonenal ; NRF2 ; Nuclear Factor (erythroid-derived-2)-like-2 ; GCLC ; Glutamate-cysteine ligase ; catalytic subunit ; NQO1 ; NAD(P)H dehydrogenase quinone-1 ; GSTP1 ; Glutathione-S-transferase-P ; S&F ; Solt and Farber model ; DEN ; Schiffer protocol ; AHF ; Altered hepatocyte foci ; GGT ; γ-glutamyltransferase ; IHC ; immunochemistry ; PR ; Positive remodeling nodule ; NR ; Negative remodeling nodule ; P ; Persistent nodule ; NL ; Normal Liv
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：87-99
• 全文大小：2298 K
• 卷排序：102

文摘

PTGR1 is overexpressed from preneoplasic nodules to liver tumors. Ptgr1 expression is regulated by NRF2 transcription factor in HCC. Liver tumors show NRF2 activation and a reduced redox status. PTGR1 prevents cell death induced by oxidative stress and promotes proliferation.