Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae)

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• 作者：André ; de O. Feitosa^a ; Amanda Cristina S. Dias^a ; Gisele da C. Ramos^a ; Heriberto R. Bitencourt^a ; José ; Edson S. Siqueira^a ; Patrí ; cia Santana B. Marinho^a ; Andersson Barison^b ; Fernanda M.M. Ocampos^b ; Andrey Moacir do R. Marinho^a ; ^{andrey@ufpa.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Endophytic fungi ; Artemia salina ; Secondary metabolites
• 刊名：Revista Argentina de Microbiología
• 出版年：2016
• 出版时间：July-September 2016
• 年：2016
• 卷：48
• 期：3
• 页码：259-263
• 全文大小：620 K

文摘

Endophytic fungi are fungi that colonize internal tissues of plants; several biologically active compounds have been isolated from these fungi. There are few studies of compounds isolated from endophytic fungi of Amazon plants. Thus, this study aimed the isolation and structural identification of ergosterol (dFont">1), ergosterol peroxide (dFont">2), mevalonolactone (dFont">3), cytochalasin B (dFont">4) and cytochalasin H (dFont">5) from Aspergillus sp. EJC 04, an endophytic fungus from Bauhinia guianensis. The cytochalasin B (dFont">4) and the diacetate derivative of cytochalasin B (dFont">4a) showed high lethality in the brine shrimp assay. This is the first occurrence of cytochalasins in Amazonian endophytic fungi from B. guianensis.