Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration

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• 作者：Siddhesh Aras^a ; Hassan Arrabi^a ; Neeraja Purandare^a ; Maik Hü ; ttemann^a ; John Kamholz^b ; Stephan Zü ; chner^c ; Lawrence I. Grossman^a ; ^{l.grossman@wayne.edu}
• 关键词：COX ; cytochrome c oxidase ; COX4I2 ; cytochrome c oxidase subunit 4 isoform 2 ; MEF ; mouse embryonic fibroblast ; MNRR1 ; Mitochondrial Nuclear Retrograde Regulator 1 ; CMT ; Charcot-Marie-Tooth disease ; ORE ; oxygen responsive element ; RBPJκ ; Recombination Signal Binding Protein For Immunoglobulin Kappa J Region ; CXXC5 ; CXXC Finger Protein 5
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：440-448
• 全文大小：1670 K
• 卷排序：1864

文摘

MNRR1 (CHCHD2) is a stress regulator functioning in both mitochondria and nucleus In mitochondria MNRR1 binds to cytochrome c oxidase (COX) Binding to COX is promoted by tyrosine phosphorylation Phosphorylation is carried out by Abl2 kinase (ARG) MNRR1 may be a modifier gene in a family with Charcot-Marie-Tooth disease type 1A