An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling
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- 作者：Robin S.B. Williamsa ; Clive Bateb ; cbate@rvc.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's ; Parkinson's ; Neurodegeneration ; Prion ; Phospholipase A2 ; Synapse
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：566-575
- 全文大小：2140 K
文摘
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Disease associated peptides caused synapse damage in an in vitro model.
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Valproic acid protected neurons against peptide-induced synapse degeneration.
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Valproic acid reduced the Aβ-induced activation of cytoplasmic phospholipase A2.
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Valproic acid reduced the Aβ-induced increase in cholesterol concentrations.