Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis
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- 作者：Zahava Vadasza ; zahava.vadas@b-zion.org.il" class="auth_mail" title="E-mail the corresponding author ; zahava.vadasz@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yair Goldebergb ; yair.goldy@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Katty Halaszc ; katty.halasz@b-zion.org.il" class="auth_mail" title="E-mail the corresponding author ; Itzhak Rosnerd ; rosneri@tx.technion.ac.il" class="auth_mail" title="E-mail the corresponding author ; Guido Valesinie ; guido.valesini@yahoo.it" class="auth_mail" title="E-mail the corresponding author ; Fabrizio Contie ; fabricio.conti@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Carlo Perriconee ; carlo.perricone@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Zev Sthoegerf ; zev_s@clalit.org.il" class="auth_mail" title="E-mail the corresponding author ; Shira Rosenberg Bezalelf ; Athanasios G. Tzioufasg ; agtzi@med.uoa.gr" class="auth_mail" title="E-mail the corresponding author ; Nancy Agmon Levinh ; nancy.agmon-levin@sheba.health.gov.il" class="auth_mail" title="E-mail the corresponding author ; Yehuda Shoenfeldh ; shoenfel@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding author ; Elias Toubia ; elias.toubi@b-zion.org.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：BCR ; B cell receptor ; SLE ; systemic lupus erythematosus ; sCD72 ; soluble CD72 ; SLEDAI ; SLE disease activity ; dsDNA ; double-stranded DNA ; aCL ; anti-cardiolipin Ab ; Breg ; B regulatory ; Treg ; T regulatory cells ; ITIM ; immune receptor tyrosine-based inhibition motif ; MAP kinase ; mitogen-activated protein ; sCD100 ; soluble CD100 ; ANA ; anti-nuclear antibodies ; ENA ; extractable nuclear antibodies ; SEM ; standard error of the mean ; AUC ; area under the curve ; SE ; standard error ; LN ; lupus nephritis ; SSc ; sc
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：114-118
- 全文大小：458 K
文摘
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CD72 is a B cell regulatory molecule.
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Soluble CD72 is elevated in SLE.
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High levels of soluble CD72 are correlated with SLEDAI.
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High levels of soluble CD72 are correlated with kidney involvement in SLE.
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High levels of soluble CD72 are correlated with aCL and ds-DNA antibodies.
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