Korean Observational Study Network for Arthritis (KORONA): Establishment of a Prospective Multicenter Cohort for Rheumatoid Arthritis in South Korea

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• 作者：Yoon-Kyoung Sung ; MD ; PhD ; MPH^?/sup> ; ^&dagger ; ; Soo-Kyung Cho ; MD ; PhD^?/sup> ; ^&dagger ; ; Chan-Bum Choi ; MD ; PhD^?/sup> ; ^&dagger ; ; So-Yeon Park ; MD^?/sup> ; ^&dagger ; ; Jeeseon Shim ; PhD^?/sup> ; ^&dagger ; ; Joong Kyong Ahn ; MD ; PhD^&Dagger ; ; So-Young Bang ; MD ; PhD^§ ; ; Hoon-Suk Cha ; MD ; PhD^&Dagger ; ; Jung-Yoon Choe ; MD ; PhD^?/sup> ; Won Tae Chung ; MD ; PhD^¶ ; ; Minyoung Her ; MD^?? ; Seung-Jae Hong ; MD ; PhD^&dagger ; &dagger ; ; Yun Kyung Hong ; MD ; PhD^&Dagger ; &Dagger ; ; Chung-Il Joung ; MD ; PhD^§ ; § ; ; Jae-Bum Jun ; MD ; PhD^?/sup> ; Young Ok Jung ; MD ; PhD^¡Î¡Î ; Young Mo Kang ; MD ; PhD^¶ ; ¶ ; ; Dong-Yook Kim ; MD ; PhD^?? ; Hae-Rim Kim ; MD ; PhD^???/sup> ; Hyoun Ah Kim ; MD ; PhD^&dagger ; &dagger ; &dagger ; ; Jinseok Kim ; MD ; PhD^&Dagger ; &Dagger ; &Dagger ; ; Seong-Kyu Kim ; MD ; PhD^?/sup> ; Sung-Il Kim ; MD ; PhD^§ ; § ; § ; ; Tae-Hwan Kim ; MD ; PhD^?/sup> ; Tae-Jong Kim ; MD ; PhD^{¡Î¡Î?/sup>} ; Eunmi Koh ; MD ; PhD^&Dagger ; ; Choong Ki Lee ; MD ; PhD^¶ ; ¶ ; ¶ ; ; Hye-Soon Lee ; MD ; PhD^§ ; ; Jisoo Lee ; MD ; PhD^???? ; Sang-Heon Lee ; MD ; PhD^???/sup> ; Sang-Hoon Lee ; MD ; PhD^&dagger ; &dagger ; &dagger ; &dagger ; ; Shin-Seok Lee ; MD ; PhD^{¡Î¡Î?/sup>} ; Sung Won Lee ; MD ; PhD^¶ ; ; Yeon-Ah Lee ; MD ; PhD^&dagger ; &dagger ; ; Seong-Su Nah ; MD ; PhD^&Dagger ; &Dagger ; &Dagger ; &Dagger ; ; Sung-Hoon Park ; MD ; PhD^?/sup> ; Dong Hyuk Sheen ; MD ; PhD^§ ; § ; § ; § ; ; Seung-Cheol Shim ; MD ; PhD^§ ; § ; § ; § ; ; Gwan Gyu Song ; MD ; PhD^{¡Î¡Î¡Î¡Î} ; Chang-Hee Suh ; MD ; PhD^&dagger ; &dagger ; &dagger ; ; Wan-Sik Uhm ; MD ; PhD^?/sup> ; Dae-Hyun Yoo ; MD ; PhD^?/sup> ; Wan-Hee Yoo ; MD ; PhD^&Dagger ; &Dagger ; ; Bo Young Yoon ; MD ; PhD^¶ ; ¶ ; ¶ ; ¶ ; ; Sang-Cheol Bae ; MD ; PhD ; MPH^?/sup> ; ^&dagger ; ; ^{scbae@hanyang.ac.kr}
• 关键词：rheumatoid arthritis ; cohort study ; prospective study
• 刊名：Seminars in Arthritis and Rheumatism
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：41
• 期：6
• 页码：745-751
• 全文大小：889 K

文摘

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Objectives

The object of this study was to introduce the KORean Observational study Network for Arthritis (KORONA) registry with an emphasis on the design of the Korean rheumatoid arthritis (RA) national database, as well as to provide an overview of the RA patients who are currently registered in KORONA.

Methods

The KORONA was established in July 2009 by the Clinical Research Center for Rheumatoid Arthritis (CRCRA) in South Korea. KORONA is based on a prospective protocol and standard, defined data collection instruments. Demographic and clinical features, laboratory and radiologic data, health-related outcomes, treatment side effects, resource utilization, and health behaviors of the RA cohort patients are recorded in a database.

Results

A total of 23 institutions, which are about 38 % of the rheumatologic departments at tertiary academic hospitals across South Korea, are part of KORONA. The quality control of data collection and management has been performed through annual monitoring and auditing, staff training, and providing standard operation protocol by the executive committee of CRCRA. As of 31 December 2010, 4721 patients with established RA were included in KORONA, because an annual survey had started to be performed in July 2010.

Conclusions

KORONA is the first nationwide Korean RA-specific cohort and it will provide valuable ¡°real-world?information for Korean RA patients.