Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone
详细信息 查看全文
- 作者：Andrew G. Yee ; Peter S. Freestone ; Ji-Zhong Bai ; Janusz Lipski ; j.lipski@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACA ; N-(p-amylcinnamoyl) anthranilic acid ; DA ; dopamine ; DAergic ; dopaminergic ; FSCV ; fast-scan cyclic voltammetry ; KATP ; ATP-sensitive potassium channel ; LC ; Locus Coeruleus ; NA ; noradrenaline ; NAergic ; noradrenergic ; Non-DAergic ; non-dopaminergic ; PD ; Parkinson's disease ; SNc ; Substantia Nigra pars compacta ; SNr ; Substantia Nigra pars reticulata ; TRPM2 ; transient receptor potential melastatin-2 channel ; TH ; tyrosine hydroxylase ; ROS ; reactive oxygen species
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P1
- 页码：34-43
- 全文大小：1527 K
文摘
- •
Rotenone inhibited the firing of NAergic LC neurons by activating KATP channels.
- •
The toxin also increased intracellular Ca2 + by activating TRPM2 channels.
- •
Rotenone depolarised mitochondria and released H2O2 from these neurons.
- •
Responses of LC neurons were compared to nigral DAergic and non-DAergic neurons.
- •
LC neurons were less sensitive than nigral DAergic neurons to effects of rotenone.