- 作者：Angeliki Tsapanou ; MSc* ; &dagger ; ; at2859@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author ; Yian Gu ; PhD* ; Deirdre O'Shea ; MSc* ; Jennifer Manly ; PhD&Dagger ; ; § ; ; Nicole Schupf ; PhD* ; &Dagger ; ; ‖ ; Nikolaos Scarmeas ; MD ; PhD* ; &dagger ; ; &Dagger ; ; § ; ; Yaakov Stern ; PhD* ; &Dagger ; ; § ;
- 关键词：Sleep disordered breathing ; mortality ; elderly ; self-reported sleep problems ; longitudinal study
- 刊名：Journal of Stroke and Cerebrovascular Diseases
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：25
- 期：6
- 页码：1524-1531
- 全文大小：345 K
Methods
A total of 1288 participants, 65 years and older, were examined longitudinally. Sleep problems were estimated using the Medical Outcomes Study Sleep Scale examining sleep disturbance, snoring, awaken short of breath or with a headache, sleep adequacy, and sleep somnolence. Cox regression analysis was used to examine the association between sleep problems and mortality. Age, gender, education, ethnicity, and body mass index were included as covariates. In further analyses we included hypertension, diabetes, heart disease, and stroke as additional covariates.
Results
The participants were followed for up to 6 years (mean = 2.9, standard deviation = 1.1), and 239 (18.6%) participants died during the follow-up. In unadjusted models, SDB at the initial visit was associated with mortality (hazard ratio [HR] = 1.37; 95% confidence interval [CI] 1.21-1.55;
Conclusions
Our results suggest that SDB is a risk factor for mortality in a large and ethnically diverse group of older adults, independent of demographic and clinical factors. Further research is needed to examine the underlying mechanisms of this association.