• 作者：Yong Zhang^a ; ¹ ; Changyin Li^a ; ¹ ; Hu Li^a ; Yipeng Song^b ; Yixia Zhao^a ; Lili Zhai^a ; Haixia Wang^c ; Ran Zhong^a ; Huiru Tang^b ; Dahai Zhu^a ; ^{dhzhu@pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：miR-378 ; Futile cycle ; Lipolysis ; Energy homeostasis ; Obesity ; SCD1
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：5
• 期：Complete
• 页码：93-104
• 全文大小：2304 K

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Systemically administering AgomiR-378 prevents and ameliorates obesity in mice

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miR-378 transgenic mice show energy deficiency due to impaired glucose metabolism

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The impairment is caused by miR-378-activated pyruvate-PEP futile cycle in muscle

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miR-378 governs energy homeostasis by increased lipolysis via targeting Scd1 in fat

Futile cycles are generally regarded as energetically wasteful processes that are avoided in metabolic pathways. Zhang et al. demonstrate miR-378-activated pyruvate-phosphoenolpyruvate futile cycle plays a regulatory benefit for the energy homeostasis by orchestrating inter-organ crosstalk between skeletal muscle and fat in mice, resulting its implication in preventing and treating obesity.