Mu-Opioid (MOP) receptor mediated G-protein signaling is impaired in specific brain regions in a rat model of schizophrenia
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- 作者：Edina Szűcsa ; Alexandra Bü ; kib ; Gabriella Ké ; kesib ; Gyö ; ngyi Horvá ; thb ; Sá ; ndor Benyhea ; benyhe@brc.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：G-protein stimulation ; [35S]GTPγS binding ; Brain membranes ; Opioid receptors ; DAMGO ; Schizophrenia animal model
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：619
- 期：Complete
- 页码：29-33
- 全文大小：764 K
文摘
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Pain insensitivity is frequently seen in animal models of schizophrenia.
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Mu-Opiod (MOP) receptor functions are studied in brain regions of such model rats.
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MOP receptor mediated G-protein activation is markedly decreased in each areas tested.
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