Saikosaponin-d: A potential chemotherapeutics in castration resistant prostate cancer by suppressing cancer metastases and cancer stem cell phenotypes
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- 作者：Di Zhong1 ; Hui-jian Zhang1 ; Yao-dong Jiang ; Peng Wu ; Huan Qi ; Chao Cai ; Shao-bin Zheng ; 270649181@qq.com" class="auth_mail" title="E-mail the corresponding author ; Qiang Dang ; jasondang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Prostate cancer ; Saikosaponin-d ; Cancer stem cell ; EMT ; Wnt
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：10 June 2016
- 年：2016
- 卷：474
- 期：4
- 页码：722-729
- 全文大小：3052 K
文摘
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SSd inhibited growth, migration and invasion abilities of CRPC cells.
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SSd suppress CSC phenotypes and EMT of CRPC cells.
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SSd blocks Wnt/β-catenin signaling pathway in CRPC cells.
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SSd may prove to be a new form of chemotherapeutic agent for prostate cancer.