Endometriosis and pregnancy complications: a Danish cohort study

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• 作者：Maria Tø ; lbø ; ll Glavind ; M.D.^a ; ^{mariatoelboell@hotmail.com} ; Axel Forman ; Ph.D.^b ; Linn H&aring ; konsen Arendt ; M.D.^a ; ^c ; Karsten Nielsen ; M.D.^d ; Tine Brink Henriksen ; Ph.D.^a
• 关键词：Assisted reproductive technology ; cesarean section ; endometriosis ; pre-eclampsia ; preterm birth
• 刊名：Fertility and Sterility
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：107
• 期：1
• 页码：160-166
• 全文大小：298 K
• 卷排序：107

文摘

To study the association between endometriosis and risk of pre-eclampsia, cesarean section, postpartum hemorrhage, preterm birth, and small for gestational age (SGA), in a large Danish birth cohort, while taking fertility treatment into account.DesignPopulation-based study.SettingNot applicable.Patient(s)A total population of 82,793 singleton pregnancies from the Aarhus Birth Cohort (1989 through 2013); 1,213 women had a diagnosis of endometriosis, affecting 1,719 pregnancies.Intervention(s)None.Main Outcome Measure(s)Pre-eclampsia, cesarean section, postpartum hemorrhage, preterm birth, and SGA.Result(s)Endometriosis was associated with an increased risk of preterm birth (adjusted odds ratio [AOR] 1.67, 95% confidence interval [CI] 1.37–2.05), with the risk being highest for very preterm birth (AOR 1.91, 95% CI 1.16–3.15). Compared with unaffected women, women with endometriosis also had an increased risk of pre-eclampsia (AOR 1.37, 95% CI 1.06–1.77) and cesarean section (AOR 1.83, 95% CI 1.60–2.09). Assisted reproductive technology did not explain these findings. No association was found between endometriosis and postpartum hemorrhage or SGA.Conclusion(s)Women with endometriosis were at increased risk of pre-eclampsia, preterm birth, and cesarean section, irrespective of use of assisted reproductive technology.