Dietary fat and gut microbiota interactions determine diet-induced obesity in mice

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• 作者：Raphaela Kü ; beckp>1p>p> ; p>p>2p>p> ; p>p>8p> ; Catalina Bonet-Ripollp>1p>p> ; p>p>2p> ; Christina Hoffmannp>1p>p> ; p>p>2p> ; Alesia Walkerp>3p> ; Veronika Maria Mü ; llerp>1p>p> ; p>p>4p> ; Valentina Luise Schü ; ppelp>1p>p> ; p>p>5p> ; Ilias Lagkouvardosp>1p> ; Birgit Scholzp>6p> ; Karl-Heinz Engelp>6p> ; Hannelore Danielp>4p> ; Philippe Schmitt-Kopplinp>1p>p> ; p>p>3p>p> ; p>p>7p> ; Dirk Hallerp>1p>p> ; p>p>5p> ; Thomas Clavelp>1p> ; Martin Klingensporp>1p>p> ; p>p>2p>p> ; p>p>mk@tum.dep>
• 关键词：Germfree ; Energy balance ; Diet-induced obesity resistance ; High-fat diet
• 刊名：Molecular Metabolism
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：12
• 页码：1162-1174
• 全文大小：2176 K
• 卷排序：5

文摘

Cholesterol-based but not plant sterol-based high-fat diet protects germfree (GF) mice from diet-induced obesity (DIO). DIO resistant GF mice show preferential carbohydrate oxidation, higher energy expenditure and energy and fat excretion. DIO resistance in GF mice is accompanied by increased steroid hormone levels but decreased bile acid levels in the cecum. Substrate oxidation and fat excretion in DIO resistant GF mice is linked to decreased hepatic Cyp7a1 and Nr1h4 expression.