Phenotypic characterization of Grm1^crv4 mice reveals a functional role for the type 1 metabotropic glutamate receptor in bone mineralization

详细信息    查看全文

• 作者：Ilaria Musante^a ; ^{Ilaria.musante@unige.it} ; Deborah Mattinzoli^b ; ^c ; ^{deborah.mattinzoli@gmail.com} ; Lavinia Alexandra Otescu^d ; ^{lao1e13@soton.ac.uk} ; Simone Bossi^a ; ^{3041842@studenti.unige.it} ; Masami Ikehata^b ; ^c ; ^{masami.ikehata@gmail.com} ; Chiara Gentili^e ; ^{chiara.gentili@unige.it} ; Giuliana Cangemi^f ; ^{GiulianaCangemi@ospedale-gaslini.ge.it} ; Cinzia Gatti^f ; ^{cinzia.dy@gmail.com} ; Laura Emionite^g ; ^{laura.emionite@hsanmartino.it} ; Piergiorgio Messa^b ; ^c ; ^{pmessa@policlinico.mi.it} ; Roberto Ravazzolo^a ; ^h ; ^{rravazzo@unige.it} ; Maria Pia Rastaldi^b ; ^c ; ^{mariapia.rastaldi@policlinico.mi.it} ; Daniela Riccardi^d ; ^{Riccardi@cardiff.ac.uk} ; Aldamaria Puliti^a ; ^h ; ^{apuliti@unige.it}
• 关键词：mGlu1 receptor ; Grm1crv4 mouse ; Bone mineralization ; Skeletal defect ; Ataxia ; Osteoblasts
• 刊名：Bone
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：Complete
• 页码：114-123
• 全文大小：1765 K
• 卷排序：94

文摘

Mice lacking mGlu1 receptor exhibit decreased bone length and bone mineral density. In mice, mGlu1 receptor absence causes epiphyseal plate premature cessation with subsequent bone growth termination. In vitro, osteoblasts from mice lacking mGlu1 receptor show impaired mineralization. In vitro, osteoblasts lacking mGlu1 receptor express high level of osteocalcin mRNA, marker of osteoblasts mature stage.