Improved HPLC purification strategy for [¹¹C]raclopride and [¹¹C]DASB leading to high radiochemical yields and more practical high quality radiopharmaceutical formulations

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• 作者：Nick Van Laeken ; Ken Kersemans ; Dieter De Meestere ; Ingeborg Goethals ; Filip De Vos
• 关键词：[11C]raclopride ; [11C]DASB ; [11C]methyl triflate ; Analytical HPLC purification ; Quality control ; Positron emission tomography ; Small animal PET
• 刊名：Applied Radiation and Isotopes
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：78
• 期：Complete
• 页码：62-67
• 全文大小：374 K

文摘

A downscaled analytical HPLC purification strategy for [¹¹C]raclopride and [¹¹C]DASB was proposed to obtain a straightforward produced injectable solution with a substantially reduced volume. Both tracers were radiosynthesized using [¹¹C]methyl triflate, and several analytical columns, in combination with ethanol containing eluents, were examined to optimize the chromatographic resolution. This resulted in a 5 mL solution of [¹¹C]raclopride, obtained after 6 min, and a 7 mL solution of [¹¹C]DASB, obtained after 10 min, using a C16-alkylamide and CN column respectively.