Inhibition of human anthracycline reductases by emodin — A possible remedy for anthracycline resistance
详细信息 查看全文
- 作者：Jan Hintzpetera ; hintzpeter@toxi.uni-kiel.de" class="auth_mail" title="E-mail the corresponding author ; Jan Moritz Seligera ; Jakub Hofmanb ; Hans-Joerg Martina ; Vladimir Wsolb ; Edmund Masera
- 关键词：AKR ; aldo-keto reductase ; SDR ; short-chain dehydrogenase/reductase ; DAUN ; daunorubicin ; DOX ; doxorubicin ; DAUNOL ; daunorubicinol ; DOXOL ; doxorubicinol
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：293
- 期：Complete
- 页码：21-29
- 全文大小：776 K
文摘
- •
Natural and synthetic compounds were identified as inhibitors for human daunorubicin reductases.
- •
Emodin is a potent inhibitor for human daunorubicin reductases.
- •
Emodin synergistically sensitizes multiresistant human cancer cells towards daunorubicin.