Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome
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- 作者：Aleksey Chudnovskiy1 ; 2 ; 3 ; 9 ; Arthur Mortha1 ; 2 ; 3 ; 9 ; 10 ; Veronika Kana1 ; 2 ; 3 ; Andrea Kennard6 ; Juan David Ramirez5 ; 6 ; Adeeb Rahman3 ; 4 ; Romain Remark1 ; 2 ; 3 ; Ilaria Mogno4 ; Ruby Ng3 ; Sasha Gnjatic2 ; 3 ; El-ad David Amir1 ; 2 ; 3 ; Alexander Solovyov2 ; Benjamin Greenbaum2 ; Jose Clemente3 ; 4 ; Jeremiah Faith3 ; 4 ; Yasmine Belkaid7 ; 8 ; Michael E. Grigg6 ; Miriam Merad1 ; 2 ; 3 ; 11 ; miriam.merad@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tritrichomonas musculis ; commensal protist ; inflammasome ; IL-18 ; IL-1b ; microbiome ; gut dendritic cells ; gut macrophages ; colon cancer ; intestinal bacterial infection
- 刊名：Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：167
- 期：2
- 页码：444-456.e14
- 全文大小：6572 K
文摘
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A murine commensal protist named T.mu modulates colonic mucosal immunity
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T.mu reprograms colonic immunity via IRF8- and IRF4-dependent dendritic cells
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T.mu-driven IL-18 protects against enteric bacteria but promotes CRC progression
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A T.mu-related protist is highly prevalent in the stools of healthy individuals