miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia
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- 作者：Silvia Nucera1 ; 8 ; Alice Giustacchini1 ; 2 ; 8 ; Francesco Boccalatte1 ; 2 ; 8 ; Andrea Calabria1 ; Cristiana Fanciullo1 ; 2 ; Tiziana Plati1 ; Anna Ranghetti1 ; Jose Garcia-Manteiga3 ; Davide Cittaro3 ; Fabrizio Benedicenti1 ; Eric R. Lechman4 ; 5 ; John E. Dick4 ; 5 ; Maurilio Ponzoni2 ; 6 ; Fabio Ciceri2 ; 7 ; Eugenio Montini1 ; Bernhard Gentner1 ; 7 ; 9 ; gentner.bernhard@hsr.it" class="auth_mail" title="E-mail the corresponding author ; Luigi Naldini1 ; 2 ; 9 ; naldini.luigi@hsr.it" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：13 June 2016
- 年：2016
- 卷：29
- 期：6
- 页码：905-921
- 全文大小：6608 K
文摘
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Constitutive miRNA-126 expression in progenitors induces miRNA-addicted leukemia
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miRNA-126 targets cell cycle/apoptosis and p53 response genes
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miRNA-126 stabilizes B-ALL in a proliferative B cell precursor state
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Antagonizing miRNA-126 in human B-ALL reduces disease burden in a xenograft model