CD14⁺⁺ CD16⁻ monocytes are the main source of 11β-HSD type 1 after IL-4 stimulation

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• 作者：Vidya Kunnathully^a ; ^{vid1488@gmail.com} ; Macarena Gomez-Lira^b ; ^{macarena.gomezlira@univr.it} ; Giulio Bassi^c ; ^{giulio.bassi@univr.it} ; Fabio Poli^a ; ^{fabio.poli@univr.it} ; Elisa Zoratti^d ; ^{elisa.zoratti@gmail.com} ; Valentina La Verde^a ; ^{valentina.laverde@gmail.com} ; Luca Idolazzi^a ; ^{luca.idolazzi@univr.it} ; Davide Gatti^a ; ^{davide.gatti@univr.it} ; Ombretta Viapiana^a ; ^{ombretta.viapiana@univr.it} ; Silvano Adami^a ; ^{silvano.adami@univr.it} ; Maurizio Rossini^a ; ^{maurizio.rossini@univr.it}
• 关键词：CD14 ; CD14++ CD16&minus ;   ; CD16 ; CD14+ CD16+ ;   ; HTRF ; Homogeneous Time-Resolved Fluorescence ; 11β-HSDs ; 11β-hydroxysteroid dehydrogenases ; CFSE ; carboxyfluorescein-diacetate-succimidyl-ester method ; rMFI ; median fluorescence intensity
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：156-163
• 全文大小：1094 K
• 卷排序：43

文摘

IL-4 stimulated CD14 monocytes are the major source of 11β-HSD1 Maturation of CD14 to M1 phenotype is prevented by IL-4 stimulation 11β-HSD1 production is independent of CD14 maturation towards the M2 phenotype