MHC Class I Chain-Related Gene A (MICA) Donor-Recipient Mismatches and MICA-129 Polymorphism in Unrelated Donor Hematopoietic Cell Transplantations Has No Impact on Outcomes in Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, or Myelodysplastic Syndrome: A Center for International Blood and Marrow Transplant Research Study

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• 作者：Medhat Askar¹ ; ^{medhat.askar@baylorhealth.edu} ; Ronald Sobecks² ; Tao Wang³ ; Mike Haagenson⁴ ; Navneet Majhail² ; Abeer Madbouly⁴ ; Dawn Thomas² ; Aiwen Zhang² ; Katharina Fleischhauer⁵ ; Katharine Hsu⁶ ; Michael Verneris⁷ ; Stephanie J. Lee⁸ ; Stephen R. Spellman⁴ ; Marcelo Ferná ; ndez-Viñ ; a⁹
• 关键词：MICA mismatch ; HLA-B mismatch ; MICA-129 polymorphism
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：436-444
• 全文大小：663 K
• 卷排序：23

文摘

This Center for International Blood and Marrow Transplant Research study included hematopoietic cell transplantation for acute lymphoblastic leukemia, acute myeloid leukemia, and myelodysplastic syndrome The associations between MICA polymorphism and MICA mismatches with hematopoietic cell transplantation outcomes were not confirmed There was a suggestion of an association between MICA mismatches and acute graft-versus-host disease grades II to IV (not III and IV) Tight linkage disequilibrium between HLA-B and MICA alleles was observed in <50% of haplotypes