Synthesis of cholate-based pyridinium receptor and its recognition toward l-tryptophan

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• 作者：Dazhi Li ; Yunxu Yang ; Chao Yang ; Biwei Hu ; Baolong Huo ; Lingwei Xue ; Aizhi Wang ; Feifei Yu
• 关键词：Molecular recognition ; Hydrogen bonding ; Conformation ; Host ; Amino acid
• 刊名：Tetrahedron
• 出版年：11 February, 2014
• 年：2014
• 卷：70
• 期：6
• 页码：1223-1229
• 全文大小：1257 K

文摘

Four cholate-based pyridinium compounds were synthesized and their binding abilities toward unmodified amino acids were investigated by UV spectroscopy and fluorescence emission spectroscopy. Studies revealed that the recognition process involved hydrogen bonding, electrostatic force, and 蟺-蟺 interaction. The receptor 4a was found to recognize l-tryptophan specifically, and the complex was studied by ¹H NMR spectroscopy. The receptors 4b and 4c showed very little recognition ability toward l-tryptophan, indicating the important role of the benzyl group at pyridinium ring.