Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation

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• 作者：Dnyaneshwar D. Subhedar^a ; Mubarak H. Shaikh^a ; Bapurao B. Shingate^a ; ^{bapushingate@gmail.com} ; Laxman Nawale^b ; Dhiman Sarkar^b ; Vijay M. Khedkar^c ; Firoz A. Kalam Khan^d ; Jaiprakash N. Sangshetti^d
• 关键词：Antitubercular ; Antibacterial activity ; Antifungal ; Cytotoxicity ; Molecular docking study ; [DBUH][OAc] ionic liquid
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：385-399
• 全文大小：2186 K
• 卷排序：125

文摘

A series of quinolidene-rhodanine conjugates were synthesized. In vitro antitubercular activity against MTB H37Ra and M. bovis BCG strains. Structure activity relationship of quinolidene-rhodanine conjugates. Docking study against the active site of Zmp1 enzyme. Nontoxic against the HUVEC, THP-1, macrophages, A549, PANC-1 and HeLa cell lines.