Enantioselective decarboxylative Michael addition of ¦Â-ketoacids to nitroalkenes catalyzed by binaphthyl-derived organocatalysts

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• 作者：Hyoung Wook Moon ; Dae Young Kim ; ^{dyoung@sch.ac.kr}
• 关键词：Asymmetric catalysis ; Organocatalysis ; Michael addition ; ¦Ã-Nitro ketones ; Nitroalkenes
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：28 November, 2012
• 年：2012
• 卷：53
• 期：48
• 页码：6569-6572
• 全文大小：496 K

文摘

The catalytic enantioselective decarboxylative Michael addition reaction promoted by chiral bifunctional organocatalysts has been developed, allowing facile synthesis of the corresponding ¦Ã-nitro ketones with excellent enantioselectivity (up to 97 % ee). The method reported represents a valuable approach utilizing ¦Â-ketoacids as synthetic equivalents of aryl methyl ketones.