Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer
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- 作者：David A. Scott ; Brian M. Aquila ; Geraldine A. Bebernitz ; Donald J. Cook ; Les A. Dakin ; Tracy L. Deegan ; Maureen M.Hattersley ; Stephanos Ioannidis ; Paul D. Lyne ; Charles A. Omer ; Minwei Ye ; XiaoLan Zhe
- 关键词：CSF-1R ; Kinase inhibitors ; Bisamide ; Thiazole
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2008
- 出版时间：1 September 2008
- 年：2008
- 卷：18
- 期：17
- 页码：4794-4797
- 全文大小：167 K
文摘
The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples.