Knockdown of unc119c results in visual impairment and early-onset retinal dystrophy in zebrafish
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- 作者：Nir Rainya ; Talya Etziona ; Shahar Alona ; b ; Adi Pomeranza ; Yael Nisgavc ; Tami Livnatc ; Michael Bachd ; Cecilia D. Gerstnere ; Wolfgang Baehre ; f ; Yoav Gothilfa ; b ; Hadas Stiebel-Kalishg ; kalishhadas@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Uncoordinated (UNC) 119 ; Morpholino knockdown ; Zebrafish retina ; Retina degeneration
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：473
- 期：4
- 页码：1211-1217
- 全文大小：1522 K
文摘
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Zebrafish Unc119c and its interactant arl3l2 localize to retina.
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Knockdown of zebrafish Unc119c and arl3l2 leads to impaired vision.
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Unc119c knockdown results in cone transducin mistrafficking
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Unc119c knockdown results in cone degeneration.
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Zebrafish Unc119c regulates cone transducin trafficking similar to its role in mouse.