Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner

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• 作者：Wenxuan Xu^a ; Chunfeng Lu^a ; Lu Yao^a ; Feng Zhang^a ; Jiangjuan Shao^a ; Shizhong Zheng^a ; ^b ; ^{nytws@163.com}
• 关键词：ALD ; alcoholic liver disease ; ALP ; alkaline phosphatase ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; BSEP ; bile salt export pump ; CPT1 ; carnitine palmitoyltransferase I ; CYP7A1 ; cholesterol 7-alpha hydroxy-lase ; DHA ; dihydroartemisininx ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethyl sulfoxide ; FAS ; fatty acid synthase ; FBS ; fetal bovine serum ; FGF15 ; fibroblast growth factor 15 ; FXR ; farnesoid X receptor ; GAPDH ; Glyceraldehyde phosphate dehydrogenase ; H&E ; haematox
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：315
• 期：Complete
• 页码：23-34
• 全文大小：2307 K
• 卷排序：315

文摘

DHA rescues FXR expression in alcoholic livers. DHA improves alcoholic liver inflammation and steatosis in a FXR-dependent way. DHA alleviates ethanol-induced hepatocyte steatosis by activation of FXR.