Negative feedback regulation of thyrotropin subunits and pituitary deiodinases in red drum, Sciaenops ocellatus

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• 作者：R.A. Jones ; ^{rajones@bio.tamu.edu} ; W.B. Cohn ^{bcohn@bio.tamu.edu} ; A.A. Wilkes ^{awilkes@bio.tamu.edu} ; D.S. MacKenzie ^{duncan@bio.tamu.edu}
• 关键词：Thyrotropin ; Deiodinase ; Fish ; Thyroid hormone ; Negative feedback
• 刊名：General and Comparative Endocrinology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：240
• 期：Complete
• 页码：19-26
• 全文大小：1112 K
• 卷排序：240

文摘

Elevations of T3 & T4 can be achieved by immersion in hormone supplemented water. Elevated circulating T3 & T4 rapidly inhibit the pituitary expression of TSH subunits. Elevated T3 & T4 also rapidly inhibit the pituitary expression of deiodinase 3. Results consistent with TH negative feedback controlling daily TSH cycles in red drum. Regulation of pituitary deiodinase 3 may play an important role in negative feedback.