Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication

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• 作者：Sumana Chakravarty^a ; ¹ ; ^{sumanachak@iict.res.in} ; ^{sumana98@gmail.com} ; Priya Jhelum^a ; ¹ ; Unis Ahmad Bhat^b ; Wenson D Rajan^b ; Swati Maitra^a ; Salil S Pathak^b ; Anant B Patel^b ; Arvind Kumar^b ; ^{akumar@ccmb.res.in}
• 关键词：Cerebral ischemia ; Magnetic resonance imaging (MRI) ; Inflammatory markers ; Histone lysine methyl transferases (KMTs) ; Histone lysine demethylases (KDMs) ; Dimethyloxalylglycine (DMOG)
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：152-164
• 全文大小：1477 K
• 卷排序：1863

文摘

ICAO model in mice causes mild to moderate level of ischemic damage in striatum. H3K9me2 mediates stroke-induce striatal damage and subsequent repair in ICAO model. DMOG, inhibitor of JMJD's has potential to be developed as stroke therapeutics.