Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain

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• 作者：Marí ; a Velasco^a ; Catherine O'Sullivan^b ; Graham K. Sheridan^a ; ^{G.Sheridan@brighton.ac.uk}
• 关键词：Demyelination ; G protein-coupled receptor ; Lysophosphatidic acid ; Neuroinflammation ; Neuropathic pain
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PB
• 页码：608-617
• 全文大小：909 K
• 卷排序：113

文摘

Neuropathic pain (NP) is a multifactorial pathological state with no cure. Increased LPA synthesis after nerve injury can trigger demyelination, causing NP. LPA/LPAR signalling contributes to maintenance of NP. New therapeutics targeting LPA production and signalling may be effective in alleviating NP.