MicroRNA-712 restrains macrophage pro-inflammatory responses by targeting LRRK2 leading to restoration of insulin stimulated glucose uptake by myoblasts

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• 作者：Malathi Talari^a ; Tapan Kumar Singh Nayak^a ; Vasundhara Kain^a ; ¹ ; Phanithi Prakash Babu^b ; Parimal Misra^a ; Kishore V.L. Parsa^a ; ^{kishorep@drils.org} ; ^{kparsa@gmail.com}
• 关键词：miRNA/miR ; microRNA ; T2D ; Type 2 diabetes ; IP-10 ; interferon-γ-inducible protein 10 ; FFA ; free fatty acids ; BMDMs ; bone marrow derived macrophages ; ARG-1 ; arginase-1 ; YM-1 ; chitinase-1 ; LRRK2 ; leucine rich repeat kinase ; 2-NBDG ; 2-(N-(7-nitrobenz-2-oxa-1 ; 3-diazol-4-yl)Amino)-2-deoxyglucose
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：82
• 期：Complete
• 页码：1-9
• 全文大小：1305 K
• 卷排序：82

文摘

MicroRNA-712 levels are significantly down-regulated in inflamed macrophages. Forced expression of miR-712 reduced pro-inflammatory responses of macrophages. miR-712 targets 3′ UTR of LRRK2. Over-expression of miR-712 in macrophages blocked their paracrine effects on insulin sensitivity. Restoration of miR-712 expression may ameliorate inflammation induced insulin resistance.