The search for an elusive cutoff remains: Problems of binary classification of heavy drinking as an endpoint for alcohol clinical trials

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• 作者：Matthew R. Pearson^a ; ^{mateo.pearson@gmail.com} ; Adrian J. Bravo^a ; ^{ajbravo@unm.edu} ; Megan Kirouac^a ; ^b ; ^{mkirouac@unm.edu} ; Katie Witkiewitz^a ; ^b ; ^{katiew@unm.edu}
• 关键词：Heavy drinking ; Alcohol use disorders ; Alcohol treatment outcome ; Alcohol related consequences ; Receiver operating characteristics
• 刊名：Drug and Alcohol Dependence
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：171
• 期：Complete
• 页码：91-96
• 全文大小：328 K
• 卷排序：171

文摘

We attempted to create a clinically meaningful alcohol use cutoff. We conducted secondary data analyses using Project MATCH and COMBINE data. The results fail to provide support for a clinically meaningful alcohol use cutoff. Across a range of consequences, no cutoff resulted in high sensitivity/specificity. No specific level of alcohol use is a good proxy for alcohol consequences.