Brain histamine depletion enhances the behavioural sequences complexity of mice tested in the open-field: Partial reversal effect of the dopamine D2/D3 antagonist sulpiride

详细信息    查看全文

• 作者：Andrea Santangelo^a ; ^b ; ^{a.santangelo@ymail.com} ; Gustavo Provensi^a ; Alessia Costa^a ; Patrizio Blandina^a ; Valdo Ricca^a ; ^b ; Giuseppe Crescimanno^c ; Maurizio Casarrubea^c ; ¹ ; M. Beatrice Passani^d ; ¹
• 关键词：T-pattern analysis ; Multivariate analysis ; Sulpiride ; Alpha-fluoromethilhistidine ; Dopamine
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：533-542
• 全文大小：2768 K
• 卷排序：113

文摘

A role of mouse brain histamine on the temporal architecture of behaviour is proposed. Descriptive and t-pattern analyses in the open field were carried out in the study. Histamine deficient mice had a marked increase in exploratory t-patterns complexity. D2/D3 antagonism partially reverted the arrangement of exploratory t-patterns.