Arachidonic acid has protective effects on oxygen-glucose deprived astrocytes mediated through enhancement of potassium channel TREK-1 activity

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• 作者：Li Lu^a ; ¹ ; Guangru Zhang^b ; ¹ ; Chunli Song^a ; ^c ; Xuexi Wang^d ; ^{wangxuexi@lzu.edu.cn} ; Weina Qian^d ; ^e ; Zhuanling Wang^d ; Yanan Liu^a ; Sheng Gong^d ; Shuning Zhou^d
• 关键词：Arachidonic acid ; Astrocytes ; Oxygen-glucose deprivation ; TREK-1
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：636
• 期：Complete
• 页码：241-247
• 全文大小：1947 K
• 卷排序：636

文摘

AA suppressed glutamate uptake and decreased GLT-1 levels under normal conditions. AA alleviated OGD-induced astrocyte death. AA rescued the decreased glutamate uptake under OGD conditions. AA increased expression levels of GLT-1 and TREK-1 under OGD conditions.