Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones
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- 作者：Gangadhar Y. Metia ; Atulkumar A. Kambleb ; Ravindra R. Kambleb ; kamchem9@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shilpa M. Somagondb ; H.C. Devarajegowdac ; Sandhya Kumarid ; Guruprasad Kalthurd ; Satish K. Adigad
- 关键词：2H-Indol-2-ones ; Cell line ; Anti-proliferative activity ; Genotoxicity
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：221-231
- 全文大小：780 K
文摘
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Indolin-2-one derivatives 3a-h and 5i-x were synthesized.
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Compounds 3a-e, 5i-l, 5q-r were screened for in vitro anti-proliferation and genotoxicity.
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20">Growth inhibition was up to 82.05 at 10−5 M concentration.
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25">Among the tested compounds 3a-b, 3e exhibited promising anti-proliferative and genotoxic activity.
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