MoS2/Ag nanohybrid: A novel matrix with synergistic effect for small molecule drugs analysis by negative-ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
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- 作者：Yaju Zhaoa ; daisy19900911@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Guoqing Dengb ; denggqq@sina.com" class="auth_mail" title="E-mail the corresponding author ; Xiaohui Liua ; lcswyh@126.com" class="auth_mail" title="E-mail the corresponding author ; Liang Suna ; sunliang@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hui Lia ; lihui@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Quan Chengc ; quan.cheng@ucr.edu" class="auth_mail" title="E-mail the corresponding author ; Kai Xib ; xikai@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Danke Xua ; xudanke@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：MoS2/Ag ; Matrix ; Synergistic effect ; Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry ; Small molecule drugs
- 刊名：Analytica Chimica Acta
- 出版年：2016
- 出版时间：21 September 2016
- 年：2016
- 卷：937
- 期：Complete
- 页码：87-95
- 全文大小：2082 K
文摘
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MoS2/Ag nanohybrid was applied as a novel matrix in negative-ion MALDI-TOF MS.
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The MoS2/Ag nanohybrid exerted synergistic effect on the detection of small molecules.
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The MoS2/Ag nanohybrid showed good signal reproducibility and low background interferences comparing to organic matrices.
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MoS2/Ag allows simultaneous analysis of multiple drugs and quantification of acetylsalicylic acid in spiked serum samples.