A sensitive fluorescent probe for cysteine and Cu²⁺ based on 1,8-naphthalimide derivatives and its application in living cells imaging

详细信息    查看全文

• 作者：Ronghua Shen ; JingJing Yang ; Hong Luo ; Bingxiang Wang ; ^{Wangbingxiang@njnu.edu.cn} ; Yuliang Jiang
• 关键词：1 ; 8-Naphthalimide-based derivatives ; Fluorescent probe ; Detection limits ; Cells imaging
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：73
• 期：4
• 页码：373-377
• 全文大小：797 K
• 卷排序：73

文摘

A new 1,8-naphthalimide derivative (NAD) was synthesized and employed as a highly sensitive and selective probe for the detection of cysteine (Cys) and Cu2+. The terminal olefin of NAD could react with Cys and resulting in fluorescence quenching, with the adding of Cu2+, the schiff base unit of NAD could coordinate with Cu2+ and lead to a highly selective fluorescence “turn-on” response. The detection limits reached as low as 25 nM for Cys and 11 nM for Cu2+. In addition, the NAD probe can be further applied to cells imaging owing to its photostability and low cytotoxicity.