Statistical procedures for the determination of linearity, detection limits and measurement uncertainty: A deeper look into SPE-LC-Orbitrap mass spectrometry of pharmaceuticals in wastewater

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• 作者：Leendert Vergeynst ; Kenneth K&rsquo ; oreje ; Patrick De Wispelaere ; Lies Harinck ; Herman Van Langenhove ; Kristof Demeestere ; ^{Kristof.Demeestere@UGent.be}
• 关键词：High-resolution mass spectrometry ; Validation ; Linearity ; Detection limit ; Measurement uncertainty
• 刊名：Journal of Hazardous Materials
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：323
• 期：part_PA
• 页码：2-10
• 全文大小：691 K
• 卷排序：323

文摘

Lack of validation strategies that are adapted to multi-residue quantification. Matrix-dependent Orbitrap linearity: stronger deviations in solvent than in matrix. Novel method to estimate more realistically detection limits using natural isotopes. Equations to estimate measurement precision from basic validation parameters. Thoroughly validated quantitative method for pharmaceuticals in wastewater.