Infection of human airway epithelial cells by different subtypes of Dobrava-Belgrade virus reveals gene expression patterns corresponding to their virulence potential
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- 作者：Peter T. Witkowskia ; 1 ; Peter.Witkowski@charite.de" class="auth_mail" title="E-mail the corresponding author ; Daniel Bourquainb ; 1 ; Katrin Bankovb ; Brita Austea ; Piotr W. Dabrowskib ; Andreas Nitscheb ; Detlev H. Krü ; gera ; Lars Schaadeb
- 关键词：Dobrava-Belgrade virus ; Tula virus ; Hantavirus ; Interferon regulated genes ; Pathogenesis ; Host cell response ; Microarray
- 刊名：Virology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：493
- 期：Complete
- 页码：189-201
- 全文大小：2507 K
文摘
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Comparison of gene expression in cells infected with different subtypes of DOBV.
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GO enrichment analysis of gene expression microarray data and confirmation via qPCR.
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Host gene modulation by DOBV genotypes is differential and corresponding to virulence.
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Major differences were observed in the regulation of immune response genes.