H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1
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- 作者：Dezhi Zhao1 ; 4 ; Qian Zhang2 ; 4 ; Yiqi Liu1 ; 4 ; Xia Li1 ; Kai Zhao3 ; Yuanyuan Ding1 ; Zhiqing Li1 ; Qicong Shen2 ; Chunmei Wang3 ; Nan Li2 ; Xuetao Cao1 ; 2 ; 3 ; caoxt@immunol.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 April 2016
- 年：2016
- 卷：15
- 期：2
- 页码：288-299
- 全文大小：3221 K
文摘
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Kdm5a promotes NK cell activation by regulating interferon-γ production
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Kdm5a inhibits SOCS1 expression and promotes STAT4 activation
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Kdm5a is recruited to the SOCS1 promoter by p50 to maintain a repressive chromatin configuration
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Kdm5a is required for clearance of Lm