Biopolymeric self-assembled nanoparticles for enhanced antibacterial activity of Ag-based compounds

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• 作者：Dhanya Dhanyalayam^a ; ¹ ; Luca Scrivano^a ; ¹ ; Ortensia Ilaria Parisi^a ; Maria Stefania Sinicropi^a ; Antonietta Fazio^a ; Carmela Saturnino^b ; ^{saturnino@unisa.it} ; Maria Rosaria Plutino^c ; Francesca Di Cristo^d ; Francesco Puoci^a ; ^{francesco.puoci@unical.it} ; Anna Rita Cappello^a ; ² ; Pasquale Longo^e ; ²
• 关键词：Dextran ; Hydrophilic-hydrophobic polymer ; Oleic acid ; Antibacterial drug ; Polymer nanovesicles ; Silver ; N-heterocyclic carbene
• 刊名：International Journal of Pharmaceutics
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：517
• 期：1-2
• 页码：395-402
• 全文大小：868 K
• 卷排序：517

文摘

Microbial infections still remain one of the main issues for human health. The rapid development of resistance towards the most common antimicrobial drugs in bacteria represents today a challenge in the infections management. In the present work we have investigated the antibacterial activity of a group of compounds, namely silver N-heterocyclic carbene complexes, against a broad spectrum of bacteria. For the most promising compound, a biopolymeric nanocarrier has been developed, in order to potentiate the metal complex activity against both Gram +ve and Gram −ve. The polymeric nanovehicle is based on dextran, modified with oleic acid residues, that confer amphiphilic properties to the polysaccharide. We have characterized the obtained biomaterial and studied its ability to self-assemble into nanoparticles in aqueous environment. Next, the transdermal diffusion analyses have been carried out to evaluate the ability of the polymeric particles to penetrate tissues. Thanks to the strategy adopted, we have fabricated an antibacterial system to which K. pneumoniae and E. coli are the most sensitive.