Interaction of storage carbohydrates and other cyclic fluxes with central metabolism: A quantitative approach by non-stationary 13C metabolic flux analysis
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- 作者：C.A. Suarez-Mendeza ; b ; 1 ; casuarezmendez@unal.edu.co" class="auth_mail" title="E-mail the corresponding author ; M. Hanemaaijera ; 2 ; Angela ten Piericka ; b ; J.C. Woltersc ; J.J. Heijnena ; b ; S.A. Wahla ; b ; s.a.wahl@tudelft.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：2PG ; 2-phosphoglycerate ; 3PG ; 3-phosphoglycerate ; 6PG ; 6-phospho gluconate ; α-KG ; oxoglutarate ; ALA ; alanine ; ASP ; aspartate ; CoA ; coenzyme-A ; DHAP ; dihydroxy acetone phosphate ; E4P ; erythrose-4-phosphate ; F6P ; fructose-6-phosphate ; FBP ; fructose-1 ; 6-bis-phosphate ; FUM ; fumarate ; G1P ; glucose-1-phosphate ; G6P ; glucose-6-phosphate ; GAP ; glyceraldehyde-3-phosphate ; GLN ; glutamine ; GLU ; glutamate ; GLY ; glycine ; Iso-Cit ; isocitrate ; LEU ; leucine ; LYS ; lysine ; MAL ; malate ; METH ; methionine ; OAA ; oxal
- 刊名：Metabolic Engineering Communications
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：3
- 期：Complete
- 页码：52-63
- 全文大小：878 K
文摘
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Cyclic fluxes between large metabolite pools and central C-metabolism are studied.
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Cyclic fluxes are rearranged depending on growth rate.
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Impact of storage carbohydrate recycle is more significant at low growth rates.
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Impact of exchange fluxes with amino acids is more significant at high growth rates.
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Trehalose export and degradation seem to play a major role in glucose recycle.