Genetic variations in TCF7L2 influence therapeutic response to sulfonylureas in Indian diabetics
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- 作者：Dipali Dhawan<sup> ; sup><sup>dipali.dhawan@gmail.comsup> ; Harish Padh
- 关键词：TCF7L2 ; Variations ; Diabetes ; Sulfonylureas
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：35-40
- 全文大小：742 K
- 卷排序：121
文摘
60% of sulfonylurea users did not achieve a target HbA1c levels of ⩽6.5% (48 mmol/mol) (which denotes good control in diabetics). Genotype influenced response to sulfonylureas, with more treatment failure in the TT homozygotes in case of rs12255372 and rs4506565. The GG genotype at rs12255372 favourably influences treatment success with sulfonylurea therapy in patients with type 2 diabetes (p ⩽ 0.05). At rs12255372, 70.5% GT or TT genotype failed to achieve therapeutic target, an absolute difference of 19% compared to GG homozygotes.