Synthesis and characterizations of water-based ferrofluids of substituted ferrites [Fe_1−xB_xFe₂O₄, B=Mn, Co (x=0–1)] for biomedical applications

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• 作者：Jyotsnendu Giri ; Pallab Pradhan ; Vaibhav Somani ; Hitesh Chelawat ; Shreerang Chhatre ; Rinti Banerjee ; Dhirendra Bahadur
• 关键词：Ferrite nanoparticle ; Ferrofluid ; Biocompatibility
• 刊名：Journal of Magnetism and Magnetic Materials
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：320
• 期：5
• 页码：724-730
• 全文大小：544 K

文摘

Nanomagnetic particles have great potential in the biomedical applications like MRI contrast enhancement, magnetic separation, targeting delivery and hyperthermia. In this paper, we have explored the possibility of biomedical applications of [Fe_1−xB_xFe₂O₄, B=Mn, Co] ferrite. Superparamagnetic particles of substituted ferrites [Fe_1−xB_xFe₂O₄, B=Mn, Co (x=0–1)] and their fatty acid coated water base ferrofluids have been successfully prepared by co-precipitation technique using NH4OH/TMAH (Tetramethylammonium hydroxide) as base. In vitro cytocompatibility study of different magnetic fluids was done using HeLa (human cervical carcinoma) cell lines. Co²⁺-substituted ferrite systems (e.g. CoFe₂O₄) is more toxic than Mn²⁺-substituted ferrite systems (e.g. MnFe₂O₄, Fe_0.6Mn_0.4Fe₂O₄). The later is as cytocompatible as Fe₃O₄. Thus, Fe_1−xMn_xFe₂O₄ could be useful in biomedical applications like MRI contrast agent and hyperthermia treatment of cancer.