Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents
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- 作者：Jean-S¨¦bastien Wattez ; Rozenn Ravallec ; Benoit Cudennec ; Claude Knauf ; Pascal Dhulster ; Philippe Valet ; Christophe Breton ; Didier Vieau ; Jean Lesage
- 关键词：Apelin ; Cholecystokinin ; Glucagon-like peptide 1 ; STC-1 cells ; Rat
- 刊名：Peptides
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：48
- 期：Complete
- 页码：134-136
- 全文大小：513 K
文摘
Apelin is an enteric peptide that exerts several digestive functions such as stimulation of cell proliferation and cholecystokinin (CCK) secretion. We investigated using murine enteroendocrine cell line (STC-1) and rats if apelin-13 stimulates both CCK and glucagon-like peptide 1 (GLP-1) secretions. We demonstrated that, in vitro and in vivo, apelin-13 increases the release of these two hormones in a dose-dependent manner. Present data suggest that apelin may modulate digestive functions, food intake behavior and glucose homoeostasis via apelin-induced release of enteric CCK but also through a new incretin-releasing activity on enteric GLP-1.