Applications of imaging flow cytometry in the diagnostic assessment of acute leukaemia

详细信息    查看全文

• 作者：Lizz F. Grimwade^a ; Kathryn A. Fuller^b ; Wendy N. Erber^b ; ^{wendy.erber@uwa.edu.au}
• 关键词：Leukaemia ; Phenotype ; Fluorescence in situ hybridization ; Acute promyelocytic leukaemia ; Nucleophosmin ; Imaging flow cytometry
• 刊名：Methods
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：112
• 期：Complete
• 页码：39-45
• 全文大小：1229 K
• 卷排序：112

文摘

Imaging flow cytometry can be applied to the diagnosis of acute leukaemia. This can be used to detect disrupted PML bodies in acute promyelocytic leukaemia. Nucleophosmin localisation can be determined in acute myeloid leukaemia. Fluorescence in situ hybridisation can be performed on intact phenotyped cells. Potential to integrate all leukaemia diagnostic tests by imaging flow cytometry.