Influence of Statin Therapy on Aneurysm Sac Regression after Endovascular Aortic Repair

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• 作者：Wonho Kim ; MD^a ; ^b ; ^c ; Ripal T. Gandhi ; MD^a ; Constantino S. Peñ ; a ; MD^a ; Raul E. Herrera ; MD^a ; Melanie B. Schernthaner ; MD^a ; Juan M. Acuñ ; a ; MD^b ; Victor N. Becerra ; BS^b ; Barry T. Katzen ; MD^a ; ^{btkatzen@aol.com}
• 关键词：AAA ; abdominal aortic aneurysm ; CAD ; coronary artery disease ; CI ; confidence interval ; EVAR ; endovascular aneurysm repair ; MMP ; matrix metalloproteinase ; OR ; odds ratio
• 刊名：Journal of Vascular and Interventional Radiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：35-43
• 全文大小：591 K
• 卷排序：28

文摘

To determine whether statin therapy is associated with abdominal aortic aneurysm (AAA) sac regression after endovascular aneurysm repair (EVAR).Materials and MethodsA total of 109 patients treated with EVAR were retrospectively analyzed (no-statin group, n = 45; statin group, n = 64). The primary endpoint was the incidence of AAA sac regression. To investigate independent predictors of AAA sac regression, regression analysis was performed. The mean age was 74 years (range, 55–90 y), and 87.2% of patients were men.ResultsThe no-statin group had higher rates of AAA sac regression than the statin group at 1 year (no-statin group, 66.7%; statin group, 45.3%; P = .028). The incidence of AAA sac regression increased over time in the statin group, and no statistical difference was seen between the two groups at 2 years (no-statin group, 66.7%; statin group, 57.8%; P = .350). The difference between the changes in maximum AAA diameter was significant between groups at 1 year (no-statin group vs statin group, −4.9 mm ± 5.9; P = .041), but the difference did not reach statistical significance at 2 years (no-statin group, −10.0 mm ± 10.1; statin group, −8.0 mm ± 9.6; P = .306). Statin therapy was not associated with AAA sac regression on univariate (odds ratio [OR], 0.685; 95% confidence interval [CI], 0.310–1.516; P = .351) and multivariate analyses (OR, 0.617; 95% CI, 0.215–1.772; P = .369).ConclusionsStatin therapy had no effect on AAA sac regression at 2 years. There is insufficient evidence to recommend statin therapy for AAA sac regression.