Garcinia kola aqueous suspension prevents cerebellar neurodegeneration in long-term diabetic rat - a type 1 diabetes mellitus model

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• 作者：Mohammed Farahna^a ; ^{mohammed.farahna@gmail.com} ; Paul F. Seke Etet^a ; Sayed Y. Osman^a ; ^b ; Kıymet K. Yurt^c ; Naheed Amir^d ; Lorella Vecchio^a ; Isınsu Aydin^c ; Yousef H. Aldebasi^e ; Azimullah Sheikh^d ; John C. Chijuka^e ; Sü ; leyman Kaplan^c ; Abdu Adem^d ; ^{abdu.adem@uaeu.ac.ae}
• 关键词：CAST ; Computer Assisted Stereological Toolbox ; DAB ; 3 ; 3&prime ; -diaminobenzidine hydrochloride ; Fas ; Fas receptor ; i.p. ; intraperitoneal injection ; STZ ; streptozotocin ; TNF-α ; tumor necrosis factor
• 刊名：Journal of Ethnopharmacology
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：195
• 期：Complete
• 页码：159-165
• 全文大小：1393 K
• 卷排序：195

文摘

The development of compounds able to improve metabolic syndrome and mitigate complications caused by inappropriate glycemic control in type 1 diabetes mellitus is challenging. The medicinal plant with established hypoglycemic properties Garcinia kola Heckel might have the potential to mitigate diabetes mellitus metabolic syndrome and complications.Aim of the studyWe have investigated the neuroprotective properties of a suspension of G. kola seeds in long-term type 1 diabetes mellitus rat model.Materials and methodsWistar rats, made diabetic by single injection of streptozotocin were monitored for 8 months. Then, they were administered with distilled water or G. kola oral aqueous suspension daily for 30 days. Body weight and glycemia were determined before and after treatment. After sacrifice, cerebella were dissected out and processed for stereological quantification of Purkinje cells. Histopathological and immunohistochemical analyses of markers of neuroinflammation and neurodegeneration were performed.ResultsPurkinje cell counts were significantly increased, and histopathological signs of apoptosis and neuroinflammation decreased, in diabetic animals treated with G. kola compared to diabetic rats given distilled water. Glycemia was also markedly improved and body weight restored to non-diabetic control values, following G. kola treatment.ConclusionsThese results suggest that G. kola treatment improved the general condition of long-term diabetic rats and protected Purkinje cells partly by improving the systemic glycemia and mitigating neuroinflammation.