The Drosophila IMD pathway in the activation of the humoral immune response

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• 作者：Anni Kleino ; Neal Silverman
• 关键词：20 ; 20-hydroxyecdysone ; AMP ; antimicrobial peptide ; DAP ; meso-diaminopimelic acid ; DREDD ; death-related ced-3/Nedd2-like protein ; FADD ; Fas-associated protein with Death Domain ; IAP ; inhibitor of apoptosis ; I魏B ; inhibitor of 魏B ; IKK ; I魏B kinase ; imd ; immune deficiency ; JNK ; c-Jun N-terminal kinase ; PGN ; peptidoglycan ; PGRP ; peptidoglycan recognition protein ; RHIM ; RIP homotypic interaction motif ; RIP ; receptor-interacting protein ; RNAi ; RNA interference ; TAB ; TAK1-associated binding protein 2
• 刊名：Developmental and Comparative Immunology
• 出版年：January, 2014
• 年：2014
• 卷：42
• 期：1
• 页码：25-35
• 全文大小：925 K

文摘

The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and signal transduction. While these findings have contributed to the understanding of the immune signaling in insects, they have also provided new insights in studying the mammalian NF-魏B signaling pathways. Here, we summarize the current view of the IMD pathway focusing on how it regulates the humoral immune response of Drosophila.